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Inventi Impact: Pharmacokinetics & Pharmacodynamics

Articles

  • Inventi:pkd/42973/21
    A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice
    01-Jul-2021 Research 2021 : July - September
    Sebastian Franck, Robin Michelet, Fiordiligie Casilag, Jean-Claude Sirard, Sebastian G Wicha, Charlotte Kloft

    Combining amoxicillin with the immunostimulatory toll-like receptor 4 agonist monophosphoryl lipid A (MPLA) represents an innovative approach for enhancing antibacterial treatment success. Exploiting pharmacokinetic and pharmacodynamic data from an infection model of Streptococcus pneumoniae infected mice, we aimed to evaluate the preclinical exposure-response relationship of amoxicillin with MPLA coadministration and establish a link to survival..................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Franck, Sebastian, et al. "A Model-Based Pharmacokinetic/Pharmacodynamic Analysis of the Combination of Amoxicillin and Monophosphoryl Lipid A Against S. pneumoniae in Mice." Pharmaceutics 13.4 (2021): 469. https://doi.org/10.3390/pharmaceutics13040469 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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